Probing the antibody-catalyzed water-oxidation pathway at atomic resolution.

  title={Probing the antibody-catalyzed water-oxidation pathway at atomic resolution.},
  author={Xueyong Zhu and Paul Wentworth and Anita D Wentworth and Albert Eschenmoser and Richard Allen Lerner and Ian A. Wilson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 8},
Antibodies can catalyze the generation of hydrogen peroxide (H2O2) from singlet dioxygen (1O2*) and water via the postulated intermediacy of dihydrogen trioxide (H2O3) and other trioxygen species. Nine different crystal structures were determined to elucidate the chemical consequences to the antibody molecule itself of exposure to such reactive intermediates and to provide insights into the location on the antibody where these species could be generated. Herein, we report structural evidence… CONTINUE READING


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