Probing the Unfolding Pathway of a 1-Antitrypsin *

  title={Probing the Unfolding Pathway of a 1-Antitrypsin *},
  author={Ellie L. James and James C. Whisstock and Michael G. Gore and Stephen P. Bottomley},
Protein misfolding plays a role in the pathogenesis of many diseases. a1-Antitrypsin misfolding leads to the accumulation of long chain polymers within the hepatocyte, reducing its plasma concentration and predisposing the patient to emphysema and liver disease. In order to understand the misfolding process, it is necessary to examine the folding of a1-antitrypsin through the different structures involved in this process. In this study we have used a novel technique in which unique cysteine… CONTINUE READING