Probing the Mechanisms of Drug Release from Hydroxypropylmethyl Cellulose Matrices

  title={Probing the Mechanisms of Drug Release from Hydroxypropylmethyl Cellulose Matrices},
  author={Anh Thu Pham and Ping I Lee},
  journal={Pharmaceutical Research},
The transient dynamic swelling and dissolution behavior during drug release from hydroxypropylmethyl cellulose (HPMC) matrices was investigated using fluorescein as a model drug. A new flow-through cell capable of providing a well-defined hydrodynamic condition and a non-destructive mode of operation was designed for this purpose to assess the associated moving front kinetics. The results obtained show a continuous increase in transient gel layer thickness irrespective of the polymer viscosity… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 35 extracted citations

Gastroretentive Dosage Forms for Prolonging Gastric Residence Time

International Journal of Pharmaceutical Medicine • 2012
View 4 Excerpts
Highly Influenced

A unified multicomponent stress-diffusion model of drug release from non-biodegradable polymeric matrix tablets.

Journal of controlled release : official journal of the Controlled Release Society • 2016
View 1 Excerpt

Similar Papers

Loading similar papers…