Probing the Mechanisms of Drug Release from Hydroxypropylmethyl Cellulose Matrices

@article{Pham1994ProbingTM,
  title={Probing the Mechanisms of Drug Release from Hydroxypropylmethyl Cellulose Matrices},
  author={Anh Thu Pham and Ping I Lee},
  journal={Pharmaceutical Research},
  year={1994},
  volume={11},
  pages={1379-1384}
}
The transient dynamic swelling and dissolution behavior during drug release from hydroxypropylmethyl cellulose (HPMC) matrices was investigated using fluorescein as a model drug. A new flow-through cell capable of providing a well-defined hydrodynamic condition and a non-destructive mode of operation was designed for this purpose to assess the associated moving front kinetics. The results obtained show a continuous increase in transient gel layer thickness irrespective of the polymer viscosity… CONTINUE READING

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