Probing the Human Spinal Locomotor Circuits by Phasic Step-Induced Feedback and by Tonic Electrical and Pharmacological Neuromodulation.

@article{Hofstoetter2017ProbingTH,
  title={Probing the Human Spinal Locomotor Circuits by Phasic Step-Induced Feedback and by Tonic Electrical and Pharmacological Neuromodulation.},
  author={Ursula S. Hofstoetter and Maria Knikou and Pierre A. Guertin and Karen Minassian},
  journal={Current pharmaceutical design},
  year={2017},
  volume={23 12},
  pages={
          1805-1820
        }
}
The mammalian lumbar spinal cord experimentally isolated from supraspinal and afferent feedback input remains capable of expressing some basic locomotor function when appropriately stimulated. This ability has been attributed to spinal neural circuits referred to as central pattern generators (CPGs). In individuals with a severe spinal cord injury, rhythmic activity in paralyzed leg muscles can be generated by phasic proprioceptive feedback during therapist- or robotic-assisted stepping on a… 

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