Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants.

@article{Vivaudou1997ProbingTG,
  title={Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants.},
  author={Michel Vivaudou and Kim W. Chan and Jin Sui and Lily Yeh Jan and Eitan Reuveny and Diomedes E. Logothetis},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 50},
  pages={31553-60}
}
In heart, G-protein-activated channels are complexes of two homologous proteins, GIRK1 and GIRK4. Expression of either protein alone results in barely active or non-active channels, making it difficult to assess the individual contribution of each subunit to the channel complex. The residue Phe137, located within the H5 region of GIRK1, is critical to the synergy between GIRK1 and GIRK4 (Chan, K. W., Sui, J. L., Vivaudou, M., and Logothetis, D. E. (1996) Proc. Natl. Acad. Sci. U. S. A. 93… CONTINUE READING
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Active G-protein-gated Homomeric K1 Channels

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