Probing the Effect of miRNA on siRNA-PEI Polyplexes.

Abstract

Delivery of small interfering RNA (siRNA) for silencing of aberrantly expressed genes is a promising therapy for the treatment of various genetic disorders. Polymeric carriers have been used in the design of efficient delivery systems to generate nanoscale siRNA polyplexes. Despite the great amount of research pursued on siRNA therapeutics, the underlying… (More)
DOI: 10.1021/acs.jpcb.5b00415

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