Probing the Chloroquine Resistance Locus of Plasmodium falciparum with a Novel Class of Multidentate Metal(III) Coordination Complexes*

@article{Goldberg1997ProbingTC,
  title={Probing the Chloroquine Resistance Locus of Plasmodium falciparum with a Novel Class of Multidentate Metal(III) Coordination Complexes*},
  author={Daniel E. Goldberg and V Sharma and Anna Oksman and Ilya Y. Gluzman and Thomas E. Wellems and David Piwnica-Worms},
  journal={The Journal of Biological Chemistry},
  year={1997},
  volume={272},
  pages={6567 - 6572}
}
The malaria organism Plasmodium falciparum detoxifies heme released during degradation of host erythrocyte hemoglobin by sequestering it within the parasite digestive vacuole as a polymer called hemozoin. Antimalarial agents such as chloroquine appear to work by interrupting the heme polymerization process, but their efficacy has been impaired by the emergence of drug-resistant organisms. We report here the identification of a new class of antimalarial compounds, hexadentate ethylenediamine-N,N… Expand
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