Probing receptor structure/function with chimeric G-protein-coupled receptors.

@article{Yin2004ProbingRS,
  title={Probing receptor structure/function with chimeric G-protein-coupled receptors.},
  author={Dezhong Yin and Shai Gavi and Hsien-yu Wang and Craig C. Malbon},
  journal={Molecular pharmacology},
  year={2004},
  volume={65 6},
  pages={1323-32}
}
Owing its name to an image borrowed from Greek mythology, a chimera is seen to represent a new entity created as a composite from existing creatures or, in this case, molecules. Making use of various combinations of three basic domains of the receptors (i.e., exofacial, transmembrane, and cytoplasmic segments) that couple agonist binding into activation of effectors through heterotrimeric G-proteins, molecular pharmacology has probed the basic organization, structure/function relationships of… CONTINUE READING

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