Probing p300/CBP associated factor (PCAF)-dependent pathways with a small molecule inhibitor.

Abstract

PCAF (KAT2B) belongs to the GNAT family of lysine acetyltransferases (KAT) and specifically acetylates the histone H3K9 residue and several nonhistone proteins. PCAF is also a transcriptional coactivator. Due to the lack of a PCAF KAT-specific small molecule inhibitor, the exclusive role of the acetyltransferase activity of PCAF is not well understood. Here… (More)
DOI: 10.1021/cb4000597

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