Probing interactions between HIV-1 reverse transcriptase and its DNA substrate with backbone-modified nucleotides.

Abstract

BACKGROUND To gain a molecular understanding of a biochemical process, the crystal structure of enzymes that catalyze the reactions involved is extremely helpful. Often the question arises whether conformations obtained in this way appropriately reflect the reactivity of enzymes, however. Rates that characterize transitions are therefore compulsory… (More)

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