Probing in vivo trafficking of polymer/DNA micellar nanoparticles using SPECT/CT imaging.

@article{Patil2011ProbingIV,
  title={Probing in vivo trafficking of polymer/DNA micellar nanoparticles using SPECT/CT imaging.},
  author={Rajesh R Patil and Jianhua Yu and Sangeeta Ray Banerjee and Yong Ren and Derek Leong and Xuan Jiang and Martin Pomper and Benjamin M V Tsui and Dara L. Kraitchman and Hai-Quan Mao},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2011},
  volume={19 9},
  pages={1626-35}
}
Successful translation of nonviral gene delivery to therapeutic applications requires detailed understanding of in vivo trafficking of the vehicles. This report compares the pharmacokinetic and biodistribution profiles of polyethylene glycol-b-polyphosphoramidate (PEG-b-PPA)/DNA micellar nanoparticles after administration through intravenous infusion, intrabiliary infusion, and hydrodynamic injection using single photon emission computed tomography/computed tomography (SPECT/CT) imaging… CONTINUE READING

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