Probing fundamental aspects of synaptic transmission with strontium.

  title={Probing fundamental aspects of synaptic transmission with strontium.},
  author={Matthew A. Xu-Friedman and Wade G Regehr},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={20 12},
Strontium is capable of supporting synaptic transmission, but release is dramatically different from that evoked in calcium. By measuring presynaptic strontium levels, we gain insight into the actions of strontium, which has implications for the identification of molecules involved in different aspects of synaptic transmission. We examined presynaptic divalent levels and synaptic release at the granule cell to stellate cell synapse in mouse cerebellar slices. We find that the prolonged duration… CONTINUE READING