Probing fibroblast growth factor dimerization and role of heparin-like glycosaminoglycans in modulating dimerization and signaling.

@article{Kwan2001ProbingFG,
  title={Probing fibroblast growth factor dimerization and role of heparin-like glycosaminoglycans in modulating dimerization and signaling.},
  author={C P Kwan and Ganesh Venkataraman and Zachary H. Shriver and Rajeev Raman and Danya Liu and Yifei Qi and Lyuba Varticovski and Ram Sasisekharan},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 26},
  pages={23421-9}
}
For a number of growth factors and cytokines, ligand dimerization is believed to be central to the formation of an active signaling complex. In the case of fibroblast growth factor-2 (FGF2) signaling, heparin/heparan sulfate-like glycosaminoglycans (HLGAGs) are involved through interaction with both FGF2 and its receptors (FGFRs) in assembling a tertiary complex and modulating FGF2 activity. Biochemical data have suggested different modes of HLGAG-induced FGF2 dimerization involving specific… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
8 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…