Probing embryonic tissue mechanics with laser hole drilling.

@article{Ma2009ProbingET,
  title={Probing embryonic tissue mechanics with laser hole drilling.},
  author={Xiaoyan Ma and Holley E Lynch and Peter Colin Scully and Michael S Hutson},
  journal={Physical biology},
  year={2009},
  volume={6 3},
  pages={036004}
}
We use laser hole drilling to assess the mechanics of an embryonic epithelium during development-in vivo and with subcellular resolution. We ablate a subcellular cylindrical hole clean through the epithelium and track the subsequent recoil of adjacent cells (on ms time scales). We investigate dorsal closure in the fruit fly with emphasis on apical constriction of amnioserosa cells. The mechanical behavior of this epithelium falls between that of a continuous sheet and a 2D cellular foam (a… CONTINUE READING

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