Probing conformational changes in proteins by mass spectrometry

@inproceedings{Chowdhury1990ProbingCC,
  title={Probing conformational changes in proteins by mass spectrometry},
  author={Swapan Kumar Chowdhury and Viswanatham Katta and Brian T Chait},
  year={1990}
}
Mass spectrometry has found wide application for the elucidation of the primary structures of proteins. However, with the exception of topographical studies of membrane-bound proteins, mass spectrometry has not previously been utilized to obtain information concerning in three-dimensional conformation of proteins. In the present communication, the authors describe the first use of mass spectrometry for probing conformational changes in proteins in a manner analogous to that employed in… CONTINUE READING
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