Probing cell-division phenotype space and Polo-like kinase function using small molecules

@article{Peters2006ProbingCP,
  title={Probing cell-division phenotype space and Polo-like kinase function using small molecules},
  author={U. Peters and J. Cherian and Jeffrey H. Kim and B. H. Kwok and T. Kapoor},
  journal={Nature Chemical Biology},
  year={2006},
  volume={2},
  pages={618-626}
}
Cell-permeable small molecules that inhibit their targets on fast timescales are powerful probes of cell-division mechanisms. Such inhibitors have been identified using phenotype-based screens with chemical libraries. However, the characteristics of compound libraries needed to effectively span cell-division phenotype space, to find probes that target different mechanisms, are not known. Here we show that a small collection of 100 diaminopyrimidines (DAPs) yields a range of cell-division… Expand
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