Probing biotransformation relationships among pyridoacridines by focusing on oxygenated analogues.

@article{Wenzel2003ProbingBR,
  title={Probing biotransformation relationships among pyridoacridines by focusing on oxygenated analogues.},
  author={P. Wenzel and P. Crews},
  journal={Journal of natural products},
  year={2003},
  volume={66 6},
  pages={
          873-5
        }
}
The presence of the MeO-5 in the structure 5-methoxyamphimidine (5) is unusual in the light of a recent analysis of the relationships among sponge- and tunicate-derived pyridoacridines. We explore a possible biochemical pathway, from neoamphimidine (2) to 5-methoxyamphimidine (5). The results of semiempirical and ab initio calculations are presented to help understand the relationships that favor the formation of 5 versus the formation of undiscovered bis-oxygenated pyridoacridines. 
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