Probing biomolecule recognition with electron transfer: electrochemical sensors for DNA hybridization.

@article{Napier1997ProbingBR,
  title={Probing biomolecule recognition with electron transfer: electrochemical sensors for DNA hybridization.},
  author={Mary E. Napier and Carson R. Loomis and Mark Foster Sistare and Jin-Seok Kim and Allen E. Eckhardt and Herbert H. Thorp},
  journal={Bioconjugate chemistry},
  year={1997},
  volume={8 6},
  pages={
          906-13
        }
}
Identifying infectious organisms, quantitating gene expression, and sequencing genomic DNA on chips all rely on the detection of nucleic acid hybridization. Described here is a novel assay for detection of the hybridization of products of the polymerase chain reaction using electron transfer from guanine to a transition-metal complex. The hybridization assay was modeled in solution by monitoring the cyclic voltammetry of Ru(bpy)3(2+) (bpy = 2,2'-bipyridine) in the presence of a probe strand… CONTINUE READING
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