Probing alpha-helical and beta-sheet structures of peptides at solid/liquid interfaces with SFG.

@article{Chen2005ProbingAA,
  title={Probing alpha-helical and beta-sheet structures of peptides at solid/liquid interfaces with SFG.},
  author={Xiaoyun Chen and Jie Wang and Jason J Sniadecki and Mark A Even and Zhan Chen},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2005},
  volume={21 7},
  pages={
          2662-4
        }
}
We demonstrated that sum frequency generation (SFG) vibrational spectroscopy can distinguish different secondary structures of proteins or peptides adsorbed at solid/liquid interfaces. The SFG spectrum for tachyplesin I at the polystyrene (PS)/solution interface has a fingerprint peak corresponding to the B1/B3 mode of the antiparallel beta-sheet. This peak disappeared upon the addition of dithiothreitol, which can disrupt the beta-sheet structure. The SFG spectrum indicative of the MSI594… CONTINUE READING
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