Probing Residue-Specific Water-Protein Interactions in Oriented Lipid Membranes via Solid-State NMR Spectroscopy.

Water plays a central role in membrane protein folding and function. It not only catalyzes lipid membrane self-assembly, but it is also affects the structural integrity and conformational dynamics of membrane proteins. Magic angle spinning (MAS) solid-state NMR is the technique of choice for measuring water accessibility of membrane proteins in a site… (More)