Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA.

@article{Liu2013ProbingNR,
  title={Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA.},
  author={Nian Liu and Marc Parisien and Qing Dai and Guanqun Zheng and Chuan Sheng He and Tao Pan},
  journal={RNA},
  year={2013},
  volume={19 12},
  pages={1848-56}
}
N(6)-methyladenosine (m(6)A) is the most abundant modification in mammalian mRNA and long noncoding RNA (lncRNA). Recent discoveries of two m(6)A demethylases and cell-type and cell-state-dependent m(6)A patterns indicate that m(6)A modifications are highly dynamic and likely play important biological roles for RNA akin to DNA methylation or histone modification. Proposed functions for m(6)A modification include mRNA splicing, export, stability, and immune tolerance; but m(6)A studies have been… CONTINUE READING
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