Probing Inhomogeneous Diffusion in the Microenvironments of Phase-Separated Polymers under Confinement.
@article{Shayegan2019ProbingID, title={Probing Inhomogeneous Diffusion in the Microenvironments of Phase-Separated Polymers under Confinement.}, author={Marjan Shayegan and Radin Tahvildari and Kimberly L. Metera and Lydia Kisley and Stephen W. Michnick and Sabrina Leslie}, journal={Journal of the American Chemical Society}, year={2019}, volume={141 19}, pages={ 7751-7757 } }
Biomolecular condensates formed by liquid-liquid phase separation of proteins and nucleic acids have been recently discovered to be prevalent in biology. These dynamic condensates behave like biochemical reaction vessels, but little is known about their structural organization and biophysical properties, which are likely related to condensate size. Thus, it is critical that we study them on scales found in vivo. However, previous in vitro studies of condensate assembly and physical properties…
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