Probing Binding Pocket of Serotonin Transporter by Single Molecular Force Spectroscopy on Living Cells*

@inproceedings{Wildling2012ProbingBP,
  title={Probing Binding Pocket of Serotonin Transporter by Single Molecular Force Spectroscopy on Living Cells*},
  author={Linda Wildling and Christian Rankl and Thomas Haselgruebler and Hermann J Gruber and Marion Holy and Amy Hauck Newman and M F Zou and Ruiyue Zhu and Michael Freissmuth and Harald H. Sitte and P. Hinterdorfer},
  booktitle={The Journal of biological chemistry},
  year={2012}
}
The serotonin transporter (SERT) terminates neurotransmission by removing serotonin from the synaptic cleft. In addition, it is the site of action of antidepressants (which block the transporter) and of amphetamines (which induce substrate efflux). The interaction energies involved in binding of such compounds to the transporter are unknown. Here, we used atomic force microscopy (AFM) to probe single molecular interactions between the serotonin transporter and MFZ2-12 (a potent cocaine analog… CONTINUE READING

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