Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist.

@article{Calderon1994ProbesFN,
  title={Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist.},
  author={S. Calderon and R. Rothman and F. Porreca and J. Flippen-Anderson and R. Mcnutt and H. Xu and L. Smith and E. Bilsky and P. Davis and K. Rice},
  journal={Journal of medicinal chemistry},
  year={1994},
  volume={37 14},
  pages={
          2125-8
        }
}
Ovarian hormones influence corticotropin releasing factor receptor colocalization with delta opioid receptors in CA1 pyramidal cell dendrites
TLDR
New insights are provided on opioid-stress system interaction in the hippocampus of both males and females and potential mechanisms through which DOR activation may influence CRF receptor activity are established. Expand
Ligand-Directed Trafficking of the δ-Opioid Receptor In Vivo: Two Paths Toward Analgesic Tolerance
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Investigating the long-term consequences of ligand-biased trafficking of the δ-opioid receptor revealed a novel aspect of biased agonism in vivo, which was produced by anatomically restricted adaptations leading to pain-specific tolerance. Expand
Behavioral effects of the delta-selective opioid agonist SNC80 and related compounds in rhesus monkeys.
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The behavioral effects of the nonpeptidic delta opioid agonist SNC80 and a series of related piperazinyl benzamides derived from the parent compound BW373U86 were evaluated in rhesus monkeys, indicating that SNC 80 functions as a systemically active, delta-selective agonist with a rapid onset of action in rhesis monkeys. Expand
Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors.
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This review comprises a comprehensive overview of biased ligands in addition to their bias factors at individual members of the opioid family of receptors, as well as bifunctional ligands. Expand
Agonist-induced phosphorylation bar code and differential post-activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies
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These studies provide novel tools and insights for ligand-activated DOP signaling in vitro and in vivo and suggest that DOP agonist efficacies may determine receptor post-activation signaling. Expand
Delta Opioid Receptor Inverse Agonists and Their in vivo Pharmacological Effects.
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This review will survey the developed δ opioid receptor inverse agonists and summarize the possible in vivo pharmacological effects by δ opioids receptors inverse agonist. Expand
Delta-opioid receptor-mediated modulation of excitability of individual hippocampal neurons: mechanisms involved.
TLDR
The behavioral effects of SNC80 and naltrindole, observed in previous studies, might be mediated, at least in part, via the modulatory effect of these ligands on the excitability of hippocampal neurons. Expand
Chiral benzene backbone-based sulfoxide-olefin ligands for highly enantioselective Rh-catalyzed addition of arylboronic acids to N-tosylarylimines
An efficient Rh-catalyzed addition of arylboronic acids to N-tosylarylimines has been developed with chiral benzene backbone-based sulfoxide-olefin ligands, where 2-methoxy-1-naphthyl sulfinylExpand
Homology modeling and 3D-QSAR study of benzhydrylpiperazine δ opioid receptor agonists
TLDR
The binding affinity of a series of benzhydrylpiperazine δ opioid receptor agonists were pooled and evaluated by using 3D-QSAR and homology modeling/molecular docking methods and showed that hydrogen bond and hydrophobic interactions played major roles in ligand-receptor interactions. Expand
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