Probenecid-treatment reduces demyelination induced by cuprizone feeding.

Abstract

Recent experiments showed that a pannexin-1 inhibitor, probenecid, reduced clinical symptoms in the murine experimental autoimmune encephalomyelitis when applied during the initial phase of neuronal inflammation. An inflammatory component is also present in a toxically induced inflammation and demyelination using cuprizone diet. Probenecid is a pannexin-1… (More)
DOI: 10.1016/j.jchemneu.2017.06.003

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