Probenecid interacts with the pharmacokinetics of morphine-6-glucuronide in humans.

  title={Probenecid interacts with the pharmacokinetics of morphine-6-glucuronide in humans.},
  author={Carsten Skarke and Martin Langer and Marwan Jarrar and Helmut Schmidt and Gerd 7 Geisslinger and J{\"o}rn L{\"o}tsch},
  volume={101 6},
BACKGROUND Evidence obtained from porcine cell cultures and experiments in laboratory animals indicates that transmembrane transporters may play a role in the distribution of the active morphine metabolite morphine-6-glucuronide (M6G). This was evaluated in a study in healthy volunteers. METHODS Ten subjects received an intravenous M6G infusion for 30 min at a dosage of 0.5 mg/kg body weight, leading to M6G plasma concentrations approximately two to three times higher than those observed with… CONTINUE READING


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