Probenecid Inhibits the Human Bitter Taste Receptor TAS2R16 and Suppresses Bitter Perception of Salicin

@inproceedings{Greene2011ProbenecidIT,
  title={Probenecid Inhibits the Human Bitter Taste Receptor TAS2R16 and Suppresses Bitter Perception of Salicin},
  author={Tiffani A. Greene and Suzanne Alarcon and Anu Thomas and Eli Berdougo and Benjamin J. Doranz and Paul A S Breslin and Joseph B. Rucker},
  booktitle={PloS one},
  year={2011}
}
Bitter taste stimuli are detected by a diverse family of G protein-coupled receptors (GPCRs) expressed in gustatory cells. Each bitter taste receptor (TAS2R) responds to an array of compounds, many of which are toxic and can be found in nature. For example, human TAS2R16 (hTAS2R16) responds to β-glucosides such as salicin, and hTAS2R38 responds to thiourea-containing molecules such as glucosinolates and phenylthiocarbamide (PTC). While many substances are known to activate TAS2Rs, only one… CONTINUE READING
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