Probenecid, but not cystic fibrosis, alters the total and renal clearance of fexofenadine.

@article{Liu2008ProbenecidBN,
  title={Probenecid, but not cystic fibrosis, alters the total and renal clearance of fexofenadine.},
  author={Shanshan Liu and Paul M. Beringer and Levita Hidayat and A. Purush Rao and Stan Louie and Gilbert J. Burckart and Bertrand Shapiro},
  journal={Journal of clinical pharmacology},
  year={2008},
  volume={48 8},
  pages={957-65}
}
This study aims to evaluate renal P-glycoprotein (P-gp) activity in patients with cystic fibrosis. P-gp efflux activity in peripheral T cells was measured by flow cytometry in 10 cystic fibrosis and 15 healthy volunteers. Eight cystic fibrosis patients and 8 healthy volunteers were recruited into a crossover pharmacokinetic study in which participants… CONTINUE READING