Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress in young rats.

@article{Sharma1986ProbableIO,
  title={Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress in young rats.},
  author={Hari Shanker Sharma and Palash Kanti Dey},
  journal={Neuropharmacology},
  year={1986},
  volume={25 2},
  pages={161-7}
}
Exposure of young rats (9-10 weeks) to chronic summer heat (36 degrees C) or acute heat (38 degrees C, 4 hr) increased the permeability of the blood-brain barrier (BBB) to Evans blue albumin complex and [131I]sodium in different regions of the brain, which correlated well with the increased level of 5-hydroxytryptamine (5-HT) in plasma and brain. This increased permeability of the blood-brain barrier and the increased level of 5-HT were prevented by pretreatment with para-chlorophenylalanine (p… CONTINUE READING

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