Probable antibody-mediated failure of two sequential ABO-compatible hepatic allografts in a single recipient.

@article{Ratner1993ProbableAF,
  title={Probable antibody-mediated failure of two sequential ABO-compatible hepatic allografts in a single recipient.},
  author={Lee Ratner and Donna R Phelan and Elizabeth M. Brunt and Thalachallour Mohanakumar and Douglas W. Hanto},
  journal={Transplantation},
  year={1993},
  volume={55 4},
  pages={814-9}
}
Two sequential ABO-compatible orthotopic liver allografts failed, despite excellent initial posttransplant function, in a patient with preformed donor-specific alloantibodies. There was no evidence of cell-mediated rejection. Retrospective crossmatching of recipient serum, obtained immediately prior to the first transplant, revealed the presence of lymphocytotoxic antibodies directed against donor class I HLA B17, at a titer of greater than 1:32,768. Similarly, lymphocytotoxic antibodies… CONTINUE READING