Probability of DNA knotting and the effective diameter of the DNA double helix.

@article{Rybenkov1993ProbabilityOD,
  title={Probability of DNA knotting and the effective diameter of the DNA double helix.},
  author={Valentin V Rybenkov and Nicholas R. Cozzarelli and Alexander Vologodskii},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 11},
  pages={5307-11}
}
During the random cyclization of long polymer chains, knots of different types are formed. We investigated experimentally the distribution of knot types produced by random cyclization of phage P4 DNA via its long cohesive ends. The simplest knots (trefoils) predominated, but more complex knots were also detected. The fraction of knots greatly diminished with decreasing solution Na+ concentration. By comparing these experimental results with computer simulations of knotting probability, we… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 72 extracted citations

Similar Papers

Loading similar papers…