# Probability distribution of molecular evolutionary trees: A new method of phylogenetic inference

@article{Rannala1996ProbabilityDO, title={Probability distribution of molecular evolutionary trees: A new method of phylogenetic inference}, author={Bruce Rannala and Ziheng Yang}, journal={Journal of Molecular Evolution}, year={1996}, volume={43}, pages={304-311} }

A new method is presented for inferring evolutionary trees using nucleotide sequence data. The birth-death process is used as a model of speciation and extinction to specify the prior distribution of phylogenies and branching times. Nucleotide substitution is modeled by a continuous-time Markov process. Parameters of the branching model and the substitution model are estimated by maximum likelihood. The posterior probabilities of different phylogenies are calculated and the phylogeny with the…

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