Probability‐based protein identification by searching sequence databases using mass spectrometry data

@article{Perkins1999ProbabilitybasedPI,
  title={Probability‐based protein identification by searching sequence databases using mass spectrometry data},
  author={David N. Perkins and Darryl J. Pappin and David M. Creasy and John S. Cottrell},
  journal={ELECTROPHORESIS},
  year={1999},
  volume={20}
}
Several algorithms have been described in the literature for protein identification by searching a sequence database using mass spectrometry data. In some approaches, the experimental data are peptide molecular weights from the digestion of a protein by an enzyme. Other approaches use tandem mass spectrometry (MS/MS) data from one or more peptides. Still others combine mass data with amino acid sequence data. We present results from a new computer program, Mascot, which integrates all three… 

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