Probabilistic sensitivity analysis of biochemical reaction systems.

@article{Zhang2009ProbabilisticSA,
  title={Probabilistic sensitivity analysis of biochemical reaction systems.},
  author={H Zhang and William P. Dempsey and John K. Goutsias},
  journal={The Journal of chemical physics},
  year={2009},
  volume={131 9},
  pages={094101}
}
Sensitivity analysis is an indispensable tool for studying the robustness and fragility properties of biochemical reaction systems as well as for designing optimal approaches for selective perturbation and intervention. Deterministic sensitivity analysis techniques, using derivatives of the system response, have been extensively used in the literature. However, these techniques suffer from several drawbacks, which must be carefully considered before using them in problems of systems biology. We… CONTINUE READING

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