Probabilistic sensitivity analysis for NICE technology assessment: not an optional extra.

  title={Probabilistic sensitivity analysis for NICE technology assessment: not an optional extra.},
  author={Karl Claxton and Mark John Sculpher and Christopher McCabe and Andrew Briggs and Ron L. Akehurst and Martin Buxton and J. E. Brazier and Tony O'Hagan},
  journal={Health economics},
  volume={14 4},
Recently the National Institute for Clinical Excellence (NICE) updated its methods guidance for technology assessment. One aspect of the new guidance is to require the use of probabilistic sensitivity analysis with all cost-effectiveness models submitted to the Institute. The purpose of this paper is to place the NICE guidance on dealing with uncertainty into a broader context of the requirements for decision making; to explain the general approach that was taken in its development; and to… CONTINUE READING

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