Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in 1H NMR metabonomics.

@article{Dieterle2006ProbabilisticQN,
  title={Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in 1H NMR metabonomics.},
  author={Frank Dieterle and Alfred Ross and Goetz Schlotterbeck and Hans Senn},
  journal={Analytical chemistry},
  year={2006},
  volume={78 13},
  pages={4281-90}
}
For the analysis of the spectra of complex biofluids, preprocessing methods play a crucial role in rendering the subsequent data analyses more robust and accurate. Normalization is a preprocessing method, which accounts for different dilutions of samples by scaling the spectra to the same virtual overall concentration. In the field of 1H NMR metabonomics integral normalization, which scales spectra to the same total integral, is the de facto standard. In this work, it is shown that integral… CONTINUE READING
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