Probabilistic modeling of Hi-C contact maps eliminates systematic biases to characterize global chromosomal architecture

@article{Yaffe2011ProbabilisticMO,
  title={Probabilistic modeling of Hi-C contact maps eliminates systematic biases to characterize global chromosomal architecture},
  author={Eitan Yaffe and Amos Tanay},
  journal={Nature Genetics},
  year={2011},
  volume={43},
  pages={1059-1065}
}
Hi-C experiments measure the probability of physical proximity between pairs of chromosomal loci on a genomic scale. We report on several systematic biases that substantially affect the Hi-C experimental procedure, including the distance between restriction sites, the GC content of trimmed ligation junctions and sequence uniqueness. To address these biases… CONTINUE READING