Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance.

  title={Proatherosclerotic mechanisms involving protein kinase C in diabetes and insulin resistance.},
  author={Christian Rask-Madsen and George L King},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={25 3},
In diabetes and insulin resistance, activation of protein kinase C (PKC) in vascular cells may be a key link between elevated plasma and tissue concentrations of glucose and nonesterified fatty acids and abnormal vascular cell signaling. Initial studies of PKC activation in diabetes focused on microvascular complications, but increasing evidence supports that PKC plays a role in several mechanisms promoting atherosclerosis. This review explains how PKC is thought to be activated in diabetes and… CONTINUE READING
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