Proarrhythmic response to sodium channel blockade. Theoretical model and numerical experiments.

  title={Proarrhythmic response to sodium channel blockade. Theoretical model and numerical experiments.},
  author={C. Frank Starmer and Anselmo Lastra and Vladislav V. Nesterenko and Augustus O. Grant},
  volume={84 3},
BACKGROUND The use of flecainide and encainide was terminated in the Cardiac Arrhythmia Suppression Trial because of an excess of sudden cardiac deaths in the active treatment group. Such events might arise from reentrant rhythms initiated by premature stimulation in the presence of anisotropic sodium channel availability. Drugs that bind to sodium channels increase the functional dispersion of refractoriness by slowing (a result of the drug-unbinding process) the transition from an inexcitable… CONTINUE READING


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