Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling.

@article{Adeniran2012ProarrhythmiaIK,
  title={Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling.},
  author={Ismail Adeniran and Aziza El Harchi and Jules C. Hancox and Henggui Zhang},
  journal={Cardiovascular research},
  year={2012},
  volume={94 1},
  pages={66-76}
}
AIMS One form of the short QT syndrome (SQT3) has been linked to the D172N gain-in-function mutation to Kir2.1, which preferentially increases outward current through channels responsible for inward rectifier K(+) current (I(K1)). This study investigated mechanisms by which the Kir2.1 D172N mutation facilitates and perpetuates ventricular arrhythmias. METHODS AND RESULTS The ten Tusscher et al. model for human ventricular action potentials (APs) was modified to incorporate changes to I(K1… CONTINUE READING
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