Proarrhythmia as a class effect of quinolones: increased dispersion of repolarization and triangulation of action potential predict torsades de pointes.

@article{Milberg2007ProarrhythmiaAA,
  title={Proarrhythmia as a class effect of quinolones: increased dispersion of repolarization and triangulation of action potential predict torsades de pointes.},
  author={Peter Milberg and Ekkehard Hilker and Shahram Ramtin and Yilmaz Cakir and J{\"o}rg Stypmann and Markus A. Engelen and Gerold Moennig and Nani Osada and G{\"u}nter Breithardt and Wilhelm Haverkamp and Lars Eckardt},
  journal={Journal of cardiovascular electrophysiology},
  year={2007},
  volume={18 6},
  pages={647-54}
}
BACKGROUND Numerous noncardiovascular drugs prolong repolarization and thereby increase the risk for patients to develop life-threatening tachyarrhythmias of the torsade de pointes (TdP) type. The development of TdP is an individual, patient-specific response to a repolarization-prolonging drug, depending on the repolarization reserve. The aim of the present study was to analyze the underlying mechanisms that discriminate hearts that will develop TdP from hearts that will not develop TdP. We… CONTINUE READING
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