Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53.

@article{Lopez2000ProapoptoticPP,
  title={Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53.},
  author={Charles D. Lopez and Yi Ao and Larry H Rohde and T. Adri{\'a}n de P{\'e}rez and Daniel J. O'Connor and Xin Lu and James M. Ford and Louie Naumovski},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 21},
  pages={8018-25}
}
p53 is an important mediator of the cellular stress response with roles in cell cycle control, DNA repair, and apoptosis. 53BP2, a p53-interacting protein, enhances p53 transactivation, impedes cell cycle progression, and promotes apoptosis through unknown mechanisms. We now demonstrate that endogenous 53BP2 levels increase following UV irradiation induced DNA damage in a p53-independent manner. In contrast, we found that the presence of a wild-type (but not mutant) p53 gene suppressed 53BP2… CONTINUE READING