Proapoptotic effects of NF-kappaB on cisplatin-induced cell death in auditory cell line.

@article{Chung2008ProapoptoticEO,
  title={Proapoptotic effects of NF-kappaB on cisplatin-induced cell death in auditory cell line.},
  author={Won-Ho Chung and Sung Hyun Boo and Man Ki Chung and Hyun Seok Lee and Yang-Sun Cho and Sung Hwa Hong},
  journal={Acta oto-laryngologica},
  year={2008},
  volume={128 10},
  pages={1063-70}
}
CONCLUSIONS The findings suggest that nuclear factor (NF)-kappaB is activated by cisplatin and plays a proapoptotic role during cell death in the auditory cell line HEI-OC1. OBJECTIVES Cisplatin is a very effective antineoplastic drug but in high doses it shows ototoxicity by inducing apoptosis of hair cells in the cochlea. NF-kappaB is a transcription factor regulating apoptosis in many organs and tissues. This study examined the role of NF-kappaB in the apoptotic pathway induced by… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…