Proapoptotic Requirement of Ribosomal Protein L11 in Ribosomal Stress-Challenged Cortical Neurons

@article{Slomnicki2016ProapoptoticRO,
  title={Proapoptotic Requirement of Ribosomal Protein L11 in Ribosomal Stress-Challenged Cortical Neurons},
  author={Lukasz P. Slomnicki and Justin Hallgren and Aruna Vashishta and Scott Carl Smith and Steven Robert Ellis and Michal Hetman},
  journal={Molecular Neurobiology},
  year={2016},
  volume={55},
  pages={538-553}
}
While impaired ribosomal biogenesis is observed in neurodegenerative diseases, its pathogenic contributions are not clear. For instance, it is well established that in rodent neurons, genetic inhibition of RNA-polymerase 1 that transcribes rRNA results in structural disruption of the nucleolus, neuronal apoptosis, and neurodegeneration. However, in most… CONTINUE READING