Proapoptotic Effects of Tau Cleavage Product Generated by Caspase-3

  title={Proapoptotic Effects of Tau Cleavage Product Generated by Caspase-3},
  author={C W Chung and Yu-Hyun Song and I Kim and W Yoon and Yong-Keun Jung},
  journal={Neurobiology of Disease},
Using an in vitro translation assay to screen a human brain cDNA library, we isolated the microtubule-associated protein Tau and determined it to be a caspase-3 substrate whose C-terminal cleavage occurred during neuronal apoptosis. DeltaTau, the 50-kDa cleavage product, was detected by Western blot in apoptotic cortical cells probed with anti-PHF-1 and anti-Tau-5 antibodies, but not anti-T-46 antibody which recognizes the C-terminus. Overexpression of DeltaTau in SK-N-BE2(C) cells… CONTINUE READING


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