Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells.

@article{Fischer2007ProapoptoticBP,
  title={Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells.},
  author={Silke F. Fischer and Philippe Bouillet and Kristy O'Donnell and Amanda Light and David M Tarlinton and Andreas Strasser},
  journal={Blood},
  year={2007},
  volume={110 12},
  pages={3978-84}
}
T cell-dependent B-cell immune responses induce germinal centers that are sites for expansion, diversification, and selection of antigen-specific B cells. During the immune response, antigen-specific B cells are removed in a process that favors the retention of cells with improved affinity for antigen, a cell death process inhibited by excess Bcl-2. In this study, we examined the role of the BH3-only protein Bim, an initiator of apoptosis in the Bcl-2-regulated pathway, in the programmed cell… CONTINUE READING