Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death.

@article{Coultas2004ProapoptoticBB,
  title={Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death.},
  author={Leigh Coultas and Philippe Bouillet and Edouard G. Stanley and Thomas C Brodnicki and Jerry M. Adams and Andreas Strasser},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 4},
  pages={
          1570-81
        }
}
The BH3-only members of the Bcl-2 protein family are essential for initiation of programmed cell death and stress-induced apoptosis. We have determined the expression pattern in mice of the BH3-only protein Bik, also called Blk or Nbk, and examined its physiological function by gene targeting. We found that Bik is expressed widely in the hematopoietic compartment and in endothelial cells of the venous but not arterial lineages. Nevertheless, its loss did not increase the numbers of such cells… CONTINUE READING

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