Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.

@article{Oakes2005ProapoptoticBA,
  title={Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.},
  author={Scott A. Oakes and Luca Scorrano and Joseph T. Opferman and Michael C. Bassik and Mari Nishino and Tullio Pozzan and S Stanley J. Korsmeyer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 1},
  pages={105-10}
}
Proapoptotic BCL-2 family members BAX and BAK are required for the initiation of mitochondrial dysfunction during apoptosis and for maintaining the endoplasmic reticulum (ER) Ca(2+) stores necessary for Ca(2+)-dependent cell death. Conversely, antiapoptotic BCL-2 has been shown to decrease Ca(2+) concentration in the ER. We found that Bax(-/-)Bak(-/-) double-knockout (DKO) cells have reduced resting ER Ca(2+) levels because of increased Ca(2+) leak and an increase in the Ca(2+)-permeable… CONTINUE READING
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