Proanthocyanidins inhibit mitogenic and survival-signaling in vitro and tumor growth in vivo.

@article{Meeran2008ProanthocyanidinsIM,
  title={Proanthocyanidins inhibit mitogenic and survival-signaling in vitro and tumor growth in vivo.},
  author={S. Meeran and S. Katiyar},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2008},
  volume={13},
  pages={
          887-97
        }
}
  • S. Meeran, S. Katiyar
  • Published 2008
  • Chemistry, Medicine
  • Frontiers in bioscience : a journal and virtual library
We have previously shown that treatment of human epidermoid carcinoma A431 cells with grape seed proanthocyanidins (GSPs) induces apoptosis of A431 cells. Here, we report that treatment of A431 cells with GSPs inhibits constitutive as well as EGF-induced higher levels of phosphorylated proteins of MAPK family in a dose-dependent manner. This effect is associated with the reactivation of MAP kinase phosphatases. Western blot analysis reveals that GSPs decrease: (i) the levels of… Expand
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