Proanthocyanidins from Grape Seeds Modulate the NF-κB Signal Transduction Pathways in Rats with TNBS-Induced Ulcerative Colitis.

@article{Li2011ProanthocyanidinsFG,
  title={Proanthocyanidins from Grape Seeds Modulate the NF-κB Signal Transduction Pathways in Rats with TNBS-Induced Ulcerative Colitis.},
  author={Xiaoli Li and Xiaolai Yang and Yongqing Cai and Hongmao Qin and Li Wang and Yingying Wang and Yanhui Huang and Xiaoxia Wang and Shuai Yan and Lei Wang and Xin Zhao and Wan Li and Sijia Li and Jiajia Chen and Yongjie Wu},
  journal={Molecules},
  year={2011},
  volume={16 8},
  pages={6721-31}
}
To elucidate the molecular mechanisms involved in the therapeutic effects of proanthocyanidins from grape seeds (GSPE), we explore whether GSPE regulates the inflammatory response of TNBS-induced colitis in rats at the levels of NF-κB signal transduction pathway. Rats were intragastrically administered of different doses of GSPE (100, 200 and 400 mg·kg-1) per day for seven days after ulcerative colitis (UC) was induced by intracolonic injection of 2,4,6-trinitrobenzenesulfonic acid (TNBS… CONTINUE READING

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